Late-stage neonatal metabolic acidosis

Healthy newborns develop metabolic acidosis 2 to 3 weeks after birth, which is called late metabolic acidosis of newborn. Its onset is related to the quality and quantity of protein in the diet, as well as inadequate development of renal function and excessive acid load in the kidney. Typical late-stage metabolic acidosis can occur 2 to 3 weeks after birth in preterm infants without other problems, and is characterized by poor weight gain associated with metabolic acidosis (BE-8mmol / L) (daily weight The added value is 10g). These children may be asymptomatic or show only excitement. The BE value is usually -10 to -16mmol / L. It may also affect the growth and development of the child and the body's resistance. life threatening. Late-stage metabolic acidosis is one of the most common metabolic problems in newborns, especially premature infants. It is more common in preterm and low-weight babies. The incidence of late-stage metabolic acidosis is significantly higher in preterm infants than in term infants. The incidence of very low birth weight infants at 1500g is higher. The smaller the gestational age of premature babies, the lower the birth weight and the longer the duration of metabolic acidosis.