Congenital adrenal hyperplasia

Congenital adrenal cortical hyperplasia (CAH) is a group of diseases caused by congenital defects in one or more enzymes in the adrenocortical hormone biosynthetic enzyme system, which causes changes in hormone levels such as cortisol. Often autosomal recessive. Clinically, 21-hydroxylase deficiency is the most common, accounting for more than 90%, and its incidence is about 1/4500 neonates, of which about 75% are salt-losing, followed by 11beta; -hydroxylase deficiency, About 5% to 8%, its incidence is about 1/5000 to 7000 newborns. Other types are rare.