Central bronchial granulomatosis

Bronchcentric granulomatosis (BG) is an immune disease, and its patients can be divided into those with and without asthma. The cause of BG in patients with asthma may be related to the immune response of certain Aspergillus parasitizing in the bronchi, and patients without asthma may be related to the hypersensitivity caused by inhalation of unknown antigens. The prominent feature of pathological manifestations is non-casein granuloma, which is rich in eosinophils. In the early stage, the bronchiolar mucosa was replaced by tissue cells, and then non-cheese, necrotizing granulomas were distributed in the bronchioles and destroyed. In the asthma group, more eosinophils were found in the lesions; in the non-asthma group, plasma cells were mostly found. Special staining revealed fungal hyphae in the granulomas. Pulmonary arteries and veins adjacent to the granuloma show vasculitis, but unlike WG, there is no vascular center destruction. The bronchi were dilated, and there was a tough gray-brown layered substance in the cavity. Microscopically, mucus, necrotic epithelium, inflammatory cells, eosinophils, and Charcot-Ley-den crystals were found, and fungal hyphae were found. Eosinophils and chronic inflammatory cells can be infiltrated around the bronchi, with fibrosis. A small number of patients have bronchial submucosal necrotizing granulomatous nodules and can damage tracheal cartilage.