Mucopolysaccharidosis type Ⅰ

Mucopolysaccharidoses (MPS) is a group of hereditary mucopolysaccharide metabolism disorders caused by lysosomal abnormalities. It is a congenital rheumatism caused by incomplete decomposition of glucosamine accumulation due to deficiency in enzyme activity. Its common clinical features are varying degrees of epiphyseal changes, mental retardation, visceral involvement and corneal turbidity; biochemical characteristics are acidic mucopolysaccharide catabolism defects, resulting in excessive accumulation of mucopolysaccharides in the cells, and excessive urine in the urine. Mucopolysaccharides are excreted.