Primary mixed cryoglobulinemia vasculitis

Essential mixed cryoglobulinemia (EMC) is also called purpura-arthralgia-coldglobulinemia syndrome. Clinically, it is characterized by purpuric skin lesions, joint pain, anemia, renal damage, and hypergammaglobulinemia. Meltzer (1966) first described the disease systematically on the basis of Wintrobe (1933) and Iener (1947). At the same time, it was also found that malignant tumors such as myeloma can also be associated with cryoglobulinemia, and appeared with The disease has the same clinical characteristics. In addition, diseases such as subacute bacterial endocarditis, leprosy, hemolytic anemia, acute glomerulonephritis, systemic lupus erythematosus, rheumatoid arthritis, and Sjogren syndrome can also be associated with cryoglobulinemia The cold globulinemia accompanying these diseases is called secondary cold globulinemia.