Pediatric selective immunoglobulin G subclass deficiency

A more precise definition of selective immunoglobulin G subclass deficiency should be: patients with one or more IgG subclass measurements below the normal mean age of 1.96 or below 2 standard deviations. Selective IgG subclass defects in children over 2 years of age are those with IgG1 levels below 2.50g / L, IgG2 below 0.50g / L, and IgG3 below 0.30g / L. If the assay used is not sensitive enough, normal infant IgG4 levels may not be detected.