Mendelian Disease

Single gene abnormal diseases are divided into Mendelian genetic diseases and non-Mendelian genetic diseases according to whether their genetic model complies with Mendelian genetic laws. Mendel proposed three basic laws and principles based on the results of pea hybridization experiments to explain genetic phenomena, including the law of separation, the law of free combination, and the principle of dominance. It refers to a disease caused by mutation of a pair of major genes, and its inheritance conforms to Mendel's law, so it is also called Mendelian hereditary disease.