Autoimmune liver disease

Autoimmune liver disease is a type of autoimmune disease in which the liver is a relatively specific immune pathologically damaged organ, mainly including: autoimmune hepatitis (AIH), primary biliary cirrhosis (PBS), and primary sclerosis Cholangitis (PSC) and the overlap syndrome between any two of these three diseases often coexist with extrahepatic immune diseases. The diagnosis is based on specific biochemical abnormalities, autoantibodies, and stem tissue characteristics. With the improvement of the level of awareness and diagnosis, the prevalence of autoimmune liver diseases reported at home and abroad has increased year by year, so it has received more and more attention and attention. The main manifestation is the destruction of autoimmune tolerance. The characteristic cytological changes of the immune response can be seen in liver tissue, that is, T cell infiltration. The target antigens of T cells are considered to be cytochrome P450IID6, mitochondrial pyruvate dehydrogenase (MCPD), and asialoglycoprotein receptor proteins (ASGP-R proteins), all of which are liver Cell-specific antigen.