Serum immunoglobulin E

IgE is a secreted immunoglobulin with a molecular weight of 196,000 and consists of two light chains and two heavy chains. It is produced by plasma cells in the lamina, tonsils, bronchi, gastrointestinal mucosa, etc., and is the main antibody that causes type I allergies. The most obvious basic biological characteristic is its homologous cellularity. Human IgE only Can sensitize human and monkey cells, but not allergies to other animals. IgE is the most thermally unstable of immunoglobulins. Among the five immunoglobulins, IgE has the shortest half-life, and has the highest decomposition rate and lowest synthesis rate, so it is the lowest in serum. The IgE value in normal human serum is about 0.1 ～ 0.9mg / L, which is usually slightly higher in men than in women. In patients with allergies or hypersensitivity, the serum IgE is significantly higher than that in normal people, and patients with exogenous asthma are several times higher than normal people. Therefore, the IgE content in the serum is too high, which often indicates the existence of genetic allergies or type I allergies.