Serum creatinine

The exact name of serum creatinine (Cr) is blood creatinine. Blood creatinine is generally considered to be endogenous blood creatinine, which is a product of human muscle metabolism. In muscle, creatine mainly slowly forms creatinine through an irreversible non-enzymatic dehydration reaction, is released into the blood, and is excreted with urine. Therefore, blood creatinine is closely related to the total muscle mass in the body and is not easily affected by diet. Creatinine is a small-molecule substance that can be filtered through the glomerulus and is rarely absorbed in the renal tubules. Almost all creatinine produced in the body is excreted with urine and is generally not affected by urine output. Clinical detection of serum creatinine is one of the main methods to understand renal function. It is an important indicator of renal function, and elevated serum creatinine means impaired renal function.