Angiotensin converting enzyme

ACE can catalyze the hydrolysis of angiotensin I (decapeptide) to octapeptide angiotensin II, which further constricts blood vessels and raises blood pressure. It can also act on the adrenal cortex and promote the secretion of aldosterone. Therefore, ACE is an important component of renin-angiotensin-aldosterone. ACE also catalyzes the hydrolysis of bradykinin, which has a hypotensive effect, and loses its activity. ACE is widely distributed in various tissues of the human body, and is rich in epididymis, testis, and lung. Among them, pulmonary capillary endothelial cells have the highest ACE activity.