Serum interleukin 4

Interleukin (il-4) is produced by cd4 + t cells stimulated by antigen or mitogen, and activated mast cells can also produce il-4. The human il-4 gene, like il-3 and il-5, is located on chromosome 5. Mature il-4 glycoprotein with a molecular weight of 18-19kd. The biological activities of il-4 include: Promote the division and proliferation of b cells activated by antigen or mitogen; promote the activity of tc cells; il-4 cannot stimulate the proliferation of macrophages, but can enhance the function of macrophages; il-4 Synergistic with il-3 can maintain and promote the proliferation of mast cells, which has a certain significance in the occurrence of certain sensitizing reactive diseases; can cooperate with csf, promote the proliferation of bone marrow hematopoietic precursor cells, and induce the myeloid cells to differentiate ; Inducing endothelial cells to express vascular cell adhesion molecule-1 (vcam-1) has certain significance for lymphocyte migration.