Anti-erythrocyte antibody

Anti-erythrocyte antibody (RBC antibody) was first reported by Donatht and Landsteiner in 1904. It is the first autoantibody to be elucidated in the human body. They are divided into three categories: warm antibodies (WAS), cold agglutinin antibodies (CAs), and DL antibodies. The antibody can cause autoimmune hemolytic anemia (AHA). The antiglobulin test is used to detect anti-erythrocyte antibodies. There are two kinds of antiglobulin tests: direct and indirect: direct antiglobulin tests are used to detect antibodies on the surface of red blood cells; indirect antiglobulin tests are used to detect free antibodies against red blood cells. Anti-erythrocyte antibodies to SLE and idiopathic autoimmune hemolytic anemia are warm antibodies, most of which are IgG. The most common cold antibody is the IgM antibody. SLE with hemolytic anemia is associated with cold antibodies. Anti-erythrocyte antibodies cause destruction of red blood cells and reduce the number of red blood cells.