Anti-mitochondrial antibody

Anti-mitochondrial antibody (AMA) was discovered by Maokey in 1958 for the first time in the serum of patients with primary biliary cirrhosis (PBC). It is an autoantibody with no organ specificity or species specificity. The study found that AMA is also found in patients with other autoimmune diseases. The target antigens of AMA are a variety of proteins on the mitochondrial membrane, and their components are complex. M1 to M99 components are known. M1 is the cardiolipin of the outer membrane of mitochondria; M2 is the main component of the AMA response in the serum of PBC patients, and its essence is the complex of pyruvate dehydrogenase and & alpha; -keto acid dehydrogenase on the inner membrane of mitochondria; the essence of M3 It is not clear; M4 is a sulfite oxidase; M5 is a 65kD protein; the properties of M6, M7, and M8 are unknown; M9 is a glycogen phosphorylase.