Anti-dsDNA antibody

Anti-dsDNA antibodies have very specific diagnostic significance for SLE. These anti-dsDNA antibodies are deposited on the microvascular basement membrane of various organs to react with organ-situ antigenic DNA to form immune complexes, activate the inflammatory system, and cause tissue damage. Such as lupus nephritis, autoimmune hepatitis and so on. Animal models have confirmed that macromolecular DNA is involved in the pathogenesis of SLE. Anti-dsDNA antibody has a very high titer in the serum of patients with active SLE. When the disease active period is controlled, the anti-dSDNA antibody titer decreases or disappears.