Anti-Scl-70 antibody

Douvas equals 1979 report. There is an antinuclear antibody in the sera of patients with scleroderma, and the target antigen is a non-histone protein in the nucleus. The molecular weight of mobile is 70kD, so it is called Scl-70. In 1986, Shero et al. Confirmed that the essence of Scl-70 is DNA topoisomerase-1, which has a natural molecular weight of 100kD and 70kD antigen as its degradation fragment. DNA topoisomerase-1, located in the nucleus, has a high concentration in the nucleoli. It is related to the unwinding process of DNA supercoils and plays a role in the replication and transcription of DNA double strands. This enzyme cuts the DNA strand and attaches it to the resulting free end. Therefore, the entire DNA molecule does not need to be untwisted, but only occurs in the area where it will replicate. Once a region is replicated or transcribed, the DNA double-strands recombine and the topology enzyme is released. It is a key protein with important biological functions in cells.