Pancreatic peptide

Pancreatio polypeptide (PP) is a 36-amino acid linear polypeptide hormone secreted by the PP cells of the pancreas. PP cells are affected by protein in post-meal foods. Protein is the strongest factor that stimulates PP secretion, followed by fats and sugars. The release of PP is vagal-cholinergic dependent and is regulated by the vagus nerve and can be inhibited by vagal resection and anticholinergic drugs. Duodenal acidification and endogenous CCK release can be used as the main hormone to stimulate the release of PP, which significantly increases the PP value. Elevated PP by insulin is caused by vagal nerve excitement through hypoglycemia. Growth hormone can inhibit PP release and postprandial PP levels. PP has the following physiological effects: ① Inhibiting the discharge of cholecystokinin and pancreatin, relaxes the smooth muscle of the gallbladder, reduces the pressure in the gallbladder, strengthens the common bile duct sphincter, and inhibits the discharge of bile to the duodenum. ② The entry of various foods into the small intestine has a stimulating effect on the release of PP. The physiological effect of PP is to inhibit pancreatic juice and bile secretion after meals, and to promote exogenous pancreatic secretion such as secretin and cholecystokinin. PP is strong. Inhibitor. ③ PP has a wide range of effects on the gastrointestinal tract and inhibits gastric acid secretion caused by pentagastrin. ④ PP inhibits the secretion of plasma motilin, increases the pressure of the lower esophageal sphincter, and inhibits the electrical activity of the gastric body.