Total bone marrow nucleated cells

Under normal circumstances, the entire development and evolution process of blood cells from primitive to mature stage has a certain regularity: ① Cell body size: As the blood cells develop and mature, the cell body gradually changes from large to small (the opposite of megakaryocytes). The more mature the development, the cell body Bigger. ② Nuclei from large to small, mature red blood cells have no nucleus; karyotype changes from round to irregular, granules are finally divided, and lymphocytes and plasma cell lines change little; chromatin changes from fine and loose to rough and dense; nuclear membrane Not obvious to obvious; the nucleoli goes from nothing to nothing. ③ The cell mass changes from little to more, and the lymphocytes do not change significantly. Wright's staining and Giemsa staining show that the cytoplasm changes from dark blue to light blue, mature granulocytes and red blood cells can turn pink and light red; granules are from nothing. ④ The ratio of nucleus to cytoplasm volume is from large to small. In pathological conditions, the above evolution can be disordered.