Anti-DNA antibody

Anti-deoxyribonucleic acid (DNA) antibodies can often be detected in the serum of patients with various autoimmune diseases, such as systemic lupus erythematosus (SLE), and anti-single-stranded DNA (ssDNA) antibodies can be found in various autoimmune diseases and connectives Tissue patients' blood, so there is not much diagnostic specificity. However, anti-double-stranded DNA (dsDNA) antibodies are mainly found in patients with SLE and are a relatively specific diagnostic indicator. The identification or specific detection of anti-dsDNA antibodies depends on the characteristics and purity of the dsDNA of the antigen used. In the past, non-pathogenic short membrane worms and the antigens isolated and purified therefrom were mostly used. However, in addition to indirect immunofluorescence, dsDNA antigens are often produced by genetic engineering. , Its specificity is better. Hemagglutination test Enzyme immunity is a more commonly used method for detecting anti-dsDNA antibodies, but the Farr method is still the standard reference method.