Dihydrotestosterone

Plasma dihydrotestosterone acts on the adrenal glands (prostate, seminal vesicle gland, etc.) as so-called true androgens. 5α-hydrogenase that forms this sterol is present in the cells of the accessory gonad. The complex formed by the sterol and the receptor protein in the cell enters the nucleus of the accessory gland and promotes new protein synthesis. Shows slightly stronger androgenic effects than testosterone. Although 5α-DHT exists in the form of testosterone in liver, chicken crown, etc., it does not have the effect of androgens. 5α-dihydrotestosterone is metabolized into 5α-androstane-3α-17β-diol by the action of 3α-hydroxysterol dehydrogenase and excreted from the body. Clinically used radioimmunoassay.