Urinary bile acid

Bile acid evolves from cholesterol and is the main component of bile. It is the largest amount of organic acids that the liver secretes into bile. The bile acid and chenodeoxycholic acid synthesized by liver cells with cholesterol as raw materials are called probile acids. After the bile is excreted into the intestinal tract, the enzymes of the intestinal bacterial plexus generate deoxycholic acid and bile acid, respectively, also known as secondary bile acids. Secondary bile acids are combined with glycine and taurine to form primary bound bile acids and glycine chenodeoxycholic acid, of which 95% of the primary bile acids are reabsorbed at the end of the ileum. After passing through the portal vein to the liver, hepatocytes again After ingestion, it is stored in the gallbladder. When digesting food, it is then discharged into the intestinal cavity to digest fat, forming a hepato-intestinal circulation. When hepatocytes are damaged or bile duct disease occurs, changes in bile acid are caused. Total bile acid is a sensitive indicator of liver function. When there is only slight necrosis of liver cells, total bile acid can increase, which changes earlier than bilirubin and alanine aminotransferase (ALT), and even earlier than liver tissue. Seen on biopsy.