Urea clearance disorder

Renal arteriosclerosis due to long-term increase in blood pressure will gradually affect renal function. In the early stage of hypertension, only renal arteriolar spasm is present, but clinically there are generally no obvious urinary system symptoms; in later stages, hypertension can promote the occurrence of vitreous degeneration or glomerular atherosclerosis in the renal arteries. According to biopsy results, renal arteriosclerosis accounts for 82.4% of hypertensive patients with a course of more than 4 months. When renal function is reduced, polyuria, nocturia, and other symptoms may appear, indicating that renal condensing function is reduced. If renal function is further reduced, oliguria, hematuria (mostly hematuria under the microscope), proteinuria, cast urine, phenol red excretion, urea clearance disorder, nitrogen retention, etc. may occur, and eventually uremia may occur. Hypertensive deaths from uremia range from 1.5% to 5%.