Cerebrospinal fluid substance P

Substance P is a biologically active 11 peptide substance extracted from brain or intestinal tissue. With a molecular weight of 1340, it has the effects of contracting smooth muscle and expanding blood vessels. The central nervous system has the highest levels of substantia nigra, followed by the fourth ventricle floor, hypothalamus, midbrain, hypothalamus, and caudate nucleus, etc., which are scarcely present in the cerebral cortex, with gray matter levels higher than white matter, with significantly dilated vessels and The effect of reducing peripheral resistance is related to pain afferent activity.