Marie-Bamberger syndrome

Marie-Bamberger syndrome (Marie-Bamberge syndrome) is also known as pulmonary hypertrophic osteoarthropathy, chronic pulmonary osteoarthropathy, systemic hypertrophic osteoarthropathy, secondary pulmonary osteoarthropathy. The syndrome was first reported by Bamberger (1889). The following year, Marie again identified patients with acromegaly as having deformed bones combined with chronic lung disease, and also named pulmonary proliferative osteoarthropathy. Hence the name of the syndrome. In 1963, Berman's definition of the syndrome supplemented three essential main signs: clubbing fingers; periosteal proliferation of long tubular bone ends; swelling, pain and tenderness of joints. The clubbing fingers account for 18% to 33% of chronic lung diseases and up to 60% in primary lung cancer.