Erythrocyte acetylcholine lipase

Erythrocyte acetylcholine lipase (CHE) is a hydrolytic enzyme in the lysosome. Cholinesterase is divided into true cholinesterase (erythrocyte cholinesterase) and pseudocholinesterase (plasma cholinesterase). The former is derived from nerve cells and bone marrow red blood cell lines, and is stored in nerve cells and neuromuscles. In the joints and red blood cells, it breaks down acetylcholine, which accounts for 60% of whole blood cholinesterase; acetylcholinesterase in red blood cells is a good marker of synaptic function and atropine requirements in patients with organophosphate poisoning. It also predicts the severity of the disease. When the red blood cell cholinesterase activity reaches 30%, the muscle can work normally without atropine treatment. When erythrocyte cholinesterase activity is less than 10%, muscle dysfunction occurs and a large amount of atropine treatment is required.