Anti-hepatocyte membrane-specific lipoprotein antibody

Liver specific lipoprotein (LSP) is a macromolecular lipid-associated complex consisting of more than 20 subunits with a molecular weight> 2 & times; 107 and containing a variety of phospholipids (including brain phospholipids, neurolipids , Lecithin and lysolecithin, etc.), cholesterol, fatty acids and triacylglycerols. Localized on the plasma membrane of hepatocytes, most of which are non-organ specific and some are liver specific. LSP antigens are species-specific epitopes. The antigenicity between humans and rabbits, liver and kidneys is closer. Therefore, rabbit liver can be used instead of human liver when preparing LSP antigen; mutual interference of renal disease should be considered when detecting anti-LSP antibodies. Since LSP may be the target antigen for in vivo immune pathological reactions, anti-LSP can kill autohepatocytes through antibody-dependent cell-mediated cytotoxicity (ADCC). It is believed that this may be the main factor leading to sustained damage to liver cells in vivo .