Cerebrospinal fluid protein characterization

Under normal circumstances, the protein content in the cerebrospinal fluid is much lower than the protein in the blood (the substances in the blood cannot enter the cerebrospinal fluid freely, as if a natural barrier exists). When a disease occurs in the central nervous system, the diseased tissue can directly release proteins, and various proteins in the plasma easily break through the blood-brain barrier and enter the cerebrospinal fluid. Therefore, qualitative examination of cerebrospinal fluid proteins can reflect the disease state of the central nervous system, but it is not specific.