Serum complement lysing immune complex activity

In complement CRA, the alternative activation pathway (AP) plays a leading role, and the traditional activation pathway is merely a promotion effect. The mechanism of complement CRA is that when complement interacts with IC, the C3 convertase of AP cleavages C3 in a large amount, and a large amount of C3b formed is embedded in the lattice structure of the antigen antibody and firmly binds to the antibody, so that the binding bonds of some antigen antibodies are broken. , Larger IC aggregates become smaller aggregates, which dissolve in the liquid phase.