Erythrocyte phosphoglycerate kinase

Phosphoglycerate kinase (PGK) is a key enzyme for glycolysis and an essential enzyme for the survival of every organism. The lack of this enzyme can cause disturbances in the metabolism and other functions of the organism. PGK is a monomeric, highly flexible glycolytic enzyme, which is mainly composed of two spherical structural thresholds. During the process of binding to the substrate, a significant conformational change occurs and eventually a catalytic effect occurs. This enzyme has only one type in some bacterial cells, but in most organisms it contains 2 to 3 isoenzymes. In addition to the different distribution of these isoenzymes in the organism, they also exhibit unique biological functions.