scleroderma

Scleroderma is a connective tissue disease that is characterized by localized or diffuse skin and internal organ connective tissue fibrosis, sclerosis, and atrophy. It is mainly characterized by the appearance of fibers in the skin, synovium, skeletal muscle, blood vessels, and esophagus. Or hardened. Some internal organs, such as the lungs, heart, kidneys, and large and small arteries, can have similar lesions. Some patients only develop skin sclerosis, which is called localized scleroderma; while some patients also develop visceral fibrosis and sclerosis, such as heart, lung, gastrointestinal, and kidney. Severe and poor prognosis. This disease is second only to lupus erythematosus in connective tissue disease. There are many female patients, and the ratio of female to male is about 3: 1. The age of onset is more common in 20 to 50 years. Women of childbearing age have the most incidence, and children and the elderly can also develop it. Miners and workers exposed to silicon have been reported to have more patients with scleroderma.