Massive hepatocyte necrosis

Massive hepatocyte necrosis is common in acute liver necrosis. Acute liver necrosis refers to acute jaundice hepatitis caused by various reasons. The main manifestations are rapid deepening of jaundice, nausea, vomiting, liver shrinkage, and significant liver odor within 10 days of onset. Massive hepatocyte necrosis caused by one or more factors in a short period of time, liver function is significantly reduced, serum alanine aminotransferase tends to rise after a short period of time, and then decreases rapidly; prothrombin time is significantly prolonged, and plasma albumin and total cholesterol are reduced , Blood ammonia increased. Skin and mucous membrane bleeding, ascites, lower extremity edema, proteinuria, and other neuropsychiatric symptoms such as irritability, delirium, mania, depression, and then into a coma. A few patients have convulsions, hyperreflexia, and pathological reflexes. If treatment is not timely, the patient will die due to hepatorenal syndrome, liver failure or severe bleeding within a few days. Especially severe cases can also die due to liver failure or severe bleeding before jaundice (7 to 10 days).