Increased estrogen in urine

Determination of estrogen in urine: There are three main types of estrogen in urine, namely estrone, estradiol and estriol. The normal value of estrogen is different at different stages of the menstrual cycle of women of childbearing age. The first 7 days of the menstrual cycle, the level of estrogen is very low, and then rises with the development of follicles, reaching a peak on the 13th day, called the peak of ovulation. After that, it suddenly dropped, followed by a gradual rise, and reached a peak on the 21st day, which is called the luteal peak. Later it dropped to menstruation. Functional uterine bleeding maintains estrogen levels below normal levels. Uterine amenorrhea is usually normal in estrogen levels, but ovarian function is deficient or congenital ovaries do not develop and cause amenorrhea. Its estrogen levels are low, but there are no periodic changes. Pituitary or hypothalamic amenorrhea, estrogen levels are generally low. . Patients with ovarian granulosa cell tumor and ovarian stroma cell tumor have higher estrogen levels. Ovarian granulosa cell tumor is a common tumor in ovarian cord stromal tumors. It accounts for about 40% of ovarian cord stromal tumors and is low-grade malignant. It has clinical features of late recurrence. According to its pathological morphology, it is divided into adult type granulosa cell tumor and juvenile type granulosa cell tumor. Although 97% of juvenile granulocytic tumors occur before the age of 30, the exact diagnosis is still based on the pathological changes of the tumor rather than the age of onset. Except for juvenile granular cell tumors diagnosed by pathology, the remaining granular cell tumors are collectively referred to as adult granular cell tumors. Ovarian ovarian cell tumors are basically benign tumors. It has obvious endocrine functions, tumor cells can secrete estrogen, and when luteinized or cystic changes, a few can have virilizing functions. Only one case of malignant vacuole cell tumor has been reported.