Skin and muscle thickening and fibrosis

Skin thickening and fibrosis are common in scleroderma. Scleroderma is an autoimmune disease of unknown origin, with pale or reddish skin edema, followed by dry, smooth, thickened, hardened, thinned, and shed hair, prone to intractability at the fingertips and joints Ulcers are the main clinical features. The disease is localized and systemic. The former is limited to skin and muscle damage, while the latter also affects the internal organs. The age of onset of scleroderma is seen at 20-50 years old, with more women than men. Patients with localized disease have a good prognosis, and those with systemic disease who have lung, heart, and kidney involvement will rapidly deteriorate and have a poor prognosis. Scleroderma is a category of "muscle paralysis" and "cutaneous paralysis" in Chinese medicine.