Inflammation of damaged renal tubular cells

The release of pathogenic factors from renal tubular cells means that after the cells are damaged, they will release some cytokines, such as IL-1 and tumor necrosis factor (TNFa). These cytokines will attract a series of inflammatory cells in the blood (such as white blood cells, lymphocytes, platelets, monocytes-macrophages, etc.) to infiltrate into the mesangial area, blood vessel area, and renal interstitial area, and release a series of inflammation. Sexual mediators cause an inflammatory response, which in turn promotes the phenotypic transformation of kidney intrinsic cells. At this point, the function of the kidney's intrinsic cells has changed, and a series of nephrotoxic cytokines and growth factors have begun to be released, such as: TGF-B, PDGF, Bfgf, EGF, etc. These factors can cause fibroblast proliferation in the renal interstitial And differentiate and transform into myofibroblasts.