Microthrombosis

With the role of procoagulant factors and the participation of triggering cofactors, it can cause fibrin deposition and platelet aggregation, twist into clumps to form microthrombus and block microvessels. The agglomerated platelets release procoagulants, activate thrombin, and further promote the formation and deposition of fibrin, which can lead to disseminated intravascular coagulation. If fibrin is deposited on the surface of red blood cells, it can surround and adhere to each other during the circulation process to form a large clot, which extends from the capillary to the microvenous, causing local blood flow obstruction. When the surrounding red blood cells gradually degenerate and decompose, the released hemoglobin and thromboplastin can promote blood clotting.