Brown pigmentation in nail and ear cartilage

Brown pigmentation in nails and ear cartilage is one of the clinical symptoms of brown yellow disease. Ochronosis is caused by the lack of homogentisate oxidase, which makes the phenylalanine and tyrosine intermediate metabolites ( Uric acid) can not go into a healthy search for oxidative decomposition. It accumulates in the body and darkens the skin, sclera, and cartilage. At the same time, Uric acid causes pigmentation of cartilage and other connective tissues, and degenerative joints of the spine and peripheral large joints. inflammation. It is also called brown yellow disease. On the other hand, urinary black acid is excreted with the urine, and the urine is blackened and oxidized in the urine to make the urine black. It is also called Alkaptonuria. This disease is a rare genetic disease and is rare. The prevalence rate reported abroad is 3 to 5 cases per million population. Uric acid easily deposits in cartilage and degenerates joints. Joint disease often occurs in the clinic and is called brown-yellow joint disease.