Familial nonmyeloid thyroid carcinoma

Nonmedullary thyroid carcinoma (NMTC) refers to malignant tumors derived from thyroid follicular cells, including papillary carcinoma, follicular carcinoma, and undifferentiated carcinoma, which account for most of thyroid cancer. Medullary thyroid carcinoma originates from thyroid C cells. In previous knowledge, hereditary thyroid cancer is mainly familial myeloid cancer, while non-myeloid cancer is usually sporadic. In 1955, Robinson and Orr of the UK first reported that a pair of identical twins had non-myeloid thyroid cancer. In 1975, Nemec et al reported that a pair of mother and child had non-myeloid thyroid cancer, and could clearly exclude radiation exposure and known familial diseases. As a result, foreign scholars have paid attention to the study of whether non-myeloid thyroid cancer has a genetic tendency. In recent years, more and more reports and researches on familial nonmedullary thyroid carcinoma (FNMTC) have been performed. Existing data have shown that familial non-myeloid thyroid cancer, as a part of non-myeloid thyroid cancer, has a genetic predisposition and has its unique etiology, pathology and clinical characteristics.