Phenothiazine antipsychotic poisoning

Antipsychotics (antipsychotics) refer to drugs that can treat various types of psychosis and various mental symptoms, also known as strong stabilizers or nerve blockers. Divided into five categories according to chemical structure, phenothiazine drugs can be divided into three categories according to different side chain structures: ① aliphatic (such as chlorpromazine, chlorpromazine); ② piperidines (such as methazine ); ③ Piperazines (such as perphenazine, fluphenazine, triflurazine). This class of drugs has many clinical uses, and chlorpromazine is the most widely used. The intestinal absorption of this group of drugs is very unstable after oral administration, and it has the function of inhibiting intestinal peristalsis, and the intestine often stays for a long time. After absorption, it is distributed in systemic tissues, most of which are in brain and lung tissues. It is mainly metabolized by the liver, and most of it is excreted as glucuronide or thiooxygen compounds. The excretion time of the drug is long, the half-life is 10-20 hours, and the effect can last for several days.