Myelofibrosis

Myelofibrosis (MF) is short for myelin fibrosis, which is a kind of myeloproliferative disease caused by the proliferation of collagen in bone marrow hematopoietic tissue. The fibrous tissue seriously affects hematopoietic function. "Sclerosis", "Unexplained myeloid metaplasia". This disease has different degrees of bone marrow fibrous tissue hyperplasia, and extramedullary hematopoietic mainly occurs in the spleen, followed by liver and lymph nodes. The typical clinical manifestations are promyelocytic-erythrocytic anemia, and there are more teardrop-shaped red blood cells. Bone marrow aspiration often results in dry pumping, the spleen is often significantly enlarged, and has varying degrees of osteosclerosis.