Hormone-resistant asthma

Glucocorticoids have been widely used clinically as a first-line treatment for asthma. Most patients with asthma can significantly improve clinical symptoms and pathophysiological changes within a short period of time. For children and adults with asthma diagnosed initially, both large and small doses of inhaled hormones can relieve symptoms and improve lung function. However, not all patients with asthma show efficacy on hormone therapy. Some patients have poor efficacy even if they are given hormones for a long time or in large doses. This is glucocoticoid resistant asthma (GRA). The diagnosis of hormone-resistant asthma requires clear diagnosis rules for asthma and adequate application of hormones, as well as exclusion of factors leading to hormone resistance and strict differential diagnosis. Bronchodilators are the first-line treatment for hormone-resistant asthma. Correspondingly, asthma that shows good effects on hormones is glucocoticoid sensitive asthma (GSA).