Skin leukemia

Leukemia cutis is a malignant tumor of white blood cells in the blood. It is characterized by immature white blood cells infiltrating the bone marrow and abnormal numbers of immature white blood cells in the blood. In addition, immature white blood cells often extensively infiltrate the liver, spleen, lymph nodes, and other organs including the skin. The specific damages of various types of skin leukemia clinically are spotted rash, pimples, plaques, nodules, petechiae, and palpable purpura. The histological characteristics of most skin leukemias are dense or diffuse infiltration of atypical leukocytes around blood vessels and glands, and there is no infiltration band under the epidermis. The diagnosis of skin leukemia is based on the relationship between the majority of cell types in infiltration, the identification of skin infiltration patterns, and the clinical and hematological findings. It is impossible to make a diagnosis based on the morphological characteristics of leukemia cells alone. In most cases, cytochemical and immunohistochemical examinations are required to accurately determine the source of skin leukemia. Leukemia is generally divided into the following two types: 1. Myelocytic granulocytic leukemia 2. Acute myeloid leukemia (AML) accounts for about 50% of acute myeloid leukamia. Leukemia infiltration is rare in AML. It has been reported that of 877 patients with acute myeloid leukemia, only 5 patients with AML have skin leukemia infiltration.