Pediatric allergic purpura nephritis

Henoch-Schonlein purpura (HSP) is a clinical syndrome mainly characterized by skin purpura, hemorrhagic gastroenteritis, arthritis and glomerulonephritis. Henoch-Schonlein purpura nephritis is an allergic disease with small vasculitis as the main lesion associated with vascular autoimmune damage. The basic lesions are IgA deposition in the mesangial area, mesangial cell proliferation with or without crescent formation. Renal damage most often occurs within 3 months (95%) of skin purpura. Although it has been reported that kidney damage can occur before and after 1 year of skin purpura, renal damage should generally not occur after 6 months It is easily regarded as purpuric nephritis. Kidney damage occurs in about half of children with HSP, at this time called anaphy lactoid purpura nephritis.