Bullous epidermolysis

"Epidermolysis bullosa (EB)" was first proposed by Koebner in the late 19th century to describe a non-scarring blistering skin disease, which was subsequently used to describe a group of mechanical damage to the skin and mucous membranes Polygene hereditary skin diseases characterized by susceptibility and formation of bullae are a typical group of diseases that invade the basement membrane area of ​​the skin, and internal organs can also be affected. Clinical conditions show great variability. At the same time, gene heterozygosity is also obvious, with autosomal dominant and recessive inheritance, abnormal wound repair can lead to chronic damage and scab, and metastatic cancer is also common. At present, significant progress has been made in the research of this disease, and its research methods are mainly through molecular cloning to encode some key protein-based networks that maintain the integrity of the skin hierarchy. This disease also belongs to the "pemphigus" category of Chinese medicine.