Paralytic dementia

Paralytic dementia, also known as syphilitic meningoencephalitis, is a chronic meningoencephalitis caused by Treponema pallidum invasion of the brain parenchyma, and is the most serious form of neurosyphilis. The main pathological changes are in the brain parenchyma, and may also involve other parts of the nervous system. The disease is a brain infectious disease mainly manifested by progressive mental decline to dementia and tremor. Haslam first reported the disease in 1798. Physical decline and increasing mental damage and personality decline can gradually occur, eventually leading to dementia and limb paralysis, so it is called paralytic dementia. Paralytic dementia is also known as fourth stage syphilis. It has been rare to treat illness for many years, but occasionally it may be related to inadequate treatment.