Basophilic leukemia

Basophilic leukemia (BL), first reported by Goachim et al in 1906. Basophils are the main components in blood and bone marrow. In addition to the clinical manifestations of acute leukemia, patients also Uremia caused by amineemia, skin flushing and numerous gastrointestinal symptoms. There are two types of BL: one is onset when it is onset, and the other is chronic basophilic disease with advanced CML. Some patients with acute granulocytic and mononuclear leukemia have t (6; 9) (p23; q34) abnormality. The number of basophils in the bone marrow is increased, but the peripheral blood is not increased. In patients with CML, t (9; 22 ) (q34; q11), both diseases have abnormal chromosome 9 (q34), and both have an increase in basophils, which indicates that the breakpoint gene of chromosome 9 may affect the basophils. Produced, Peterson et al. Performed ultrastructural analysis on 455 leukemia blasts in patients with acute leukemia, and found 8 cases of acute basophilic leukemia, accounting for less than 2% of acute leukemia, but Quattrin statistics from 1959 to 1973, Naples Hospital, Italy Of the 2152 cases of hematological malignancies treated, the disease accounted for 4.5% of acute leukemia. The disease was immature basophils (more than 1/3 of the total number of white blood cells) in the blood and persisted throughout the disease. process.