Opioid poisoning

Opium, morphine, codeine, paregoric, and papaverine are effective drugs for analgesia, cough, diarrhea, anesthesia, and antispasmodic. The clinical application is very wide. Opioids are commonly known as opium and smoke, and the main toxic component is morphine. The acute poisoning is usually caused by respiratory paralysis, which can be caused by misuse of large quantities or frequent application of morphine. The morphine poisoning amount is 0.06g for adults, and the lethal amount is 0.25g; the lethal amount of dry opioids is 10 times that of morphine, and the oral lethal amount is 2-5g. Codeine toxicity is 1/4 of morphine, of which the toxic dose is 0.2g and the lethal dose is 0.8g. Ingestion by mistake in large quantities or frequently can cause poisoning. Barbiturates and other hypnotic drugs work synergistically with this class of drugs, so be careful when using them together.