Meningeal cancer

Meningeal carcinomatosis (MC) refers to diffuse or multifocal pial meningeal dissemination or infiltration of malignant tumors, clinical manifestations of brain, cerebral nerve and spinal cord damage, and is a special type of central nervous system metastases The type of distribution is one of the important reasons for the death of malignant tumors. Due to the extensive development of cerebrospinal fluid cytology, prenatal diagnosis has been basically achieved. In 1870, Eberth found that cancer cells selectively invaded the pia mater from autopsy cases of lung cancer. Its early clinical manifestations were similar to meningitis, but there was no inflammation in the pathological anatomy, but cancer cell infiltration, which was called cancerous meningitis. Bearman called it meningeal cancer in 1912. The primary lesions of MC are mostly solid tumors, and the literature reports (Liu Meishi et al., 1993) mostly adenocarcinoma. It is generally believed that the primary lesions of MC are in order of incidence: gastric cancer or lung cancer, breast cancer, malignant lymphoma, malignant melanoma, pancreatic cancer, etc. There are also many MCs caused by leukemia. MC can occur before the primary lesion is confirmed, and in some cases autopsy finds the primary lesion or does not know where it is at all.