Dopa reactive dystonia

Dopa-reactive dystonia (DRD), also known as Segawa disease, is a rare genetic disease that occurs in children or adolescents with dystonia or abnormal gait as the first symptom. Its clinical characteristics are the diurnal fluctuation of symptoms, and the dramatic and persistent response of small-dose dopa preparations are its significant clinical features. All symptoms including fatigue, dystonia, abnormal posture, and tremor will completely disappear after administration. Long-term use of levodopa does not need to increase the dose, and there will be no motor complications of levodopa. Segawa et al. Described the disease for the first time in 1976, and there have been many reports abroad. In recent years, it has attracted great attention from domestic clinicians.