Pediatric hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is a clinical syndrome involving multiple systems, mainly characterized by microangiopathic hemolysis, acute renal failure, and thrombocytopenia. It is one of the common causes of acute renal failure in children. . More than 1/3 of children with HUS may have neurological involvement. Because HUS and thrombocytopenic purpura (TTP) have similarities in etiology, pathogenesis and clinical manifestations, more and more scholars believe that the two are clinical manifestations of different stages of the same disease Can be collectively referred to as HUS / TTP or thrombotic microangiopathy (TMA). HUS histopathological damage is a thrombotic microangiopathy. Many functional and pathological changes are the result of endothelial cell damage, and the kidney is the most affected. Children are more common than adults. With the improvement of diagnosis and treatment technology, the prognosis of HUS has changed.