Motor neuron disease in the elderly

Motor neuron disease (MND) is a type of degenerative disease with unknown etiology that selectively invades the motor system or a certain part of the disease. The lesions include anterior horn cells of the spinal cord, neurokinesis of the brainstem brain, and pyramidal tracts. Such diseases include amyotrophic lateral sclerosis, progressive spinal muscular atrophy, progressive bulbar palsy, and primary lateral sclerosis. After the elderly suffer from such diseases, they are called motor neuron diseases in the elderly. The pathological changes of this disease are mainly the loss of spinal anterior horn cells and the lower motor nucleus of the brainstem. Many surviving nerve cells shrink and shrink. The cytoplasm is filled with lipofuscin. Neurons with smaller neurons are affected early, the anterior roots become thinner, large myelinated fibers in motor nerves are disproportionately lost, and skeletal muscles show typical denervated muscular atrophy at different stages.